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. 2012 Mar 1;8(3):e1002402. doi: 10.1371/journal.pcbi.1002402

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Marée et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The top row represents small GTPases, the middle row depicts phosphoinositides, and at the lowest level are the cytoskeletal components. Here we explore the effects of feedback from the PIs to the small GTPases, indicated by the red dashed lines. The parameter in the model represents the magnitude of the feedback ( means the feedback is absent, means it is essential for activating Cdc42 and Rac).

Inline graphic — The top row represents small GTPases, the middle row depicts phosphoinositides, and at the lowest level are the cytoskeletal components. Here we explore the effects of feedback from the PIs to the small GTPases, indicated by the red dashed lines. The parameter in the model represents the magnitude of the feedback ( means the feedback is absent, means it is essential for activating Cdc42 and Rac).