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. 2012 Mar 1;8(3):e1002402. doi: 10.1371/journal.pcbi.1002402

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Marée et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Shown are the Rac distributions in the 2D cell [(a) and Video S1] and in a representative 1D cross-section along the cell diameter (b,c). Left panels: absent PI feedback (). Right panels: with PI feedback (). The sharp transition between high and low Rac activity is seen on the left (contours closely spaced), whereas PIs create a broader transition zone (right). Panels (b–c): schematics of differences in intracellular patterns due to maximal PI feedback to Rho proteins. (b): Inactive Rac (dot-dashed line) is nearly uniform for , but shows significant depletion close to the “front” for high . Decreasing the rate of diffusion of inactive Rac (red curves) has little effect on the profile when . In contrast, decreasing when leads to a lower peak of active Rac at the front. Panels (c): Communication of multiple peaks of active Rac is very slow in the case, and much more significant in the case . Hence, feedback from PIs helps to resolve conflicting cell “fronts”.

Inline graphic — Shown are the Rac distributions in the 2D cell [(a) and Video S1] and in a representative 1D cross-section along the cell diameter (b,c). Left panels: absent PI feedback (). Right panels: with PI feedback (). The sharp transition between high and low Rac activity is seen on the left (contours closely spaced), whereas PIs create a broader transition zone (right). Panels (b–c): schematics of differences in intracellular patterns due to maximal PI feedback to Rho proteins. (b): Inactive Rac (dot-dashed line) is nearly uniform for , but shows significant depletion close to the “front” for high . Decreasing the rate of diffusion of inactive Rac (red curves) has little effect on the profile when . In contrast, decreasing when leads to a lower peak of active Rac at the front. Panels (c): Communication of multiple peaks of active Rac is very slow in the case, and much more significant in the case . Hence, feedback from PIs helps to resolve conflicting cell “fronts”.