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. 2012 Mar 1;8(3):e1002402. doi: 10.1371/journal.pcbi.1002402

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Marée et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Cells initially polarized and moving rightwards encounter a wall (blue vertical band). (a) without feedback from PIs () the cell has difficulty resolving the competition between two nascent “fronts”; (b) with the standard intermediate feedback from PIs () the cell is able to make a decision and move smoothly along the wall; (c) with extreme feedback from PIs () the leading edge becomes confined and encircled by the contracting back, so that the cell becomes stuck. (See also Video S9.)

Inline graphic — Cells initially polarized and moving rightwards encounter a wall (blue vertical band). (a) without feedback from PIs () the cell has difficulty resolving the competition between two nascent “fronts”; (b) with the standard intermediate feedback from PIs () the cell is able to make a decision and move smoothly along the wall; (c) with extreme feedback from PIs () the leading edge becomes confined and encircled by the contracting back, so that the cell becomes stuck. (See also Video S9.)