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. 2012 Mar 1;8(3):e1002401. doi: 10.1371/journal.pcbi.1002401

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Vavoulis et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Inference of maximal conductances and noise parameters during fixed-lag smoothing. (A) The standard deviations of the observation (Ai) and the intrinsic (Aii) noise at the soma and the dendrite. (B) Inferred maximal conductances of the sodium and potassium currents at the soma (Bi), of the N-type calcium current and the calcium-activated potassium current at the soma (Bii), of the calcium-activated potassium current at the dendrite (Biii) and of the N-type and L-type calcium currents at the dendrite (Biv). In all cases, parameter expectations gradually converged towards the true parameter values (dashed lines) after less than . The grey lines in Aii, Biii and Biv correspond to estimated parameters, when current was injected in the soma only. In these simulations, , , and the prior interval for was .

Inline graphic — Inference of maximal conductances and noise parameters during fixed-lag smoothing. (A) The standard deviations of the observation (Ai) and the intrinsic (Aii) noise at the soma and the dendrite. (B) Inferred maximal conductances of the sodium and potassium currents at the soma (Bi), of the N-type calcium current and the calcium-activated potassium current at the soma (Bii), of the calcium-activated potassium current at the dendrite (Biii) and of the N-type and L-type calcium currents at the dendrite (Biv). In all cases, parameter expectations gradually converged towards the true parameter values (dashed lines) after less than . The grey lines in Aii, Biii and Biv correspond to estimated parameters, when current was injected in the soma only. In these simulations, , , and the prior interval for was .