Figure 4. Decrease of AP frequency in the presence of KA in SO CA2/3 fast-spiking interneurons PICRO–treated rats is partially relieved by the blockade of GABA receptors.

A, The GABA_A and GABA_B antagonists picrotoxin and CGP55845, respectively, induced a significant increase of AP frequency compared to recordings with KA only application (PICRO+KA plot here is the same as in Figure 1D) (ANOVA: p = 0.05, n = 7) (see red labeled symbol). It also resulted in a decrease in AHP (C). B, Representative traces recorded in slices from PICRO-treated rats (left) with KA (middle) and CGP55845 with picrotoxin (right) in the external solution. **p<0.01. Error bars are SEM.