Figure 5. ZD7288 reverses the increase of AP frequency induced by CGP55845 with picrotoxin in SO CA2/3 fast-spiking interneurons PICRO–treated rats.

A, B, Application of the Ih blocker ZD7288 significantly decreases AP frequency and increases duration (C) compared to recordings with CGP55845 (GABA_B antagonist) and picrotoxin (GABA_A antagonist) (the red labeled plot is the same as in Figure 4E) bath application (ANOVA: p = 0.02, n = 6). In contrast, bath perfusion of tertiapin-Q did not have a significant effect on interneuronal electrophysiological properties (A, B, C). Traces on the bottom of the panel were recorded with the application of KA and GABA_A,B blockers (left), tertiapin-Q- (middle) and ZD7288 (right). ***p<0.001. Error bars are SEM.