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. 2011 Nov 3;5(2):220–230. doi: 10.1242/dmm.008409

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Current-clamp recordings from human iPSC-derived cardiomyocytes. (A) Spontaneous APs from healthy control iPSC-derived (upper APs) and LQT2 patient-derived (lower APs) cardiomyocytes. The dashed line denotes 0 mV. (B) The action potential duration (APD) measured at 50% and 90% repolarization from the AP peak (APD₅₀ and APD₉₀) of spontaneous atrial-like (n=5–6) and ventricular-like APs. For the latter, both the APD₅₀ and APD₉₀ of LQT2 patient-derived cardiomyocytes (n=13) were significantly prolonged compared with those of hESCs (n=7) or control-iPSC origin (n=11). (C) Spontaneous arrhythmogenic activity of an LQT2-iPSC-derived cardiomyocyte.