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. 2011 Nov 3;5(2):220–230. doi: 10.1242/dmm.008409

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 5. — I_Kr recorded from iPSC cardiomyocytes with a ventricular-like AP. (A) Example of the isolation of I_Kr. Whole-cell current, here from a control iPS cardiomyocyte, was recorded in the absence (a) and then presence of 1 μmol/l E-4031 (b), with I_Kr defined as the subtracted current (a–b), i.e. the E-4031-sensitive current. Current was evoked by a 5-second depolarization from a holding potential of −40 mV as shown in the inset. (B) I_Kr of a control iPS (black) and LQT2 iPS (red) cardiomyocyte evoked as in A with the time segment between the arrows expanded to show the peak tail currents on return to −40 mV following a step to +20 mV. (C) The peak tail I_Kr densities of control iPSC (black; n=4) and LQT2 iPSC (red; n=5) cardiomyocytes at membrane potentials from 0 to +40 mV were significantly different (*P<0.01, **P<0.005). (D) I_Kr currents of control iPSC (black) and LQT2 iPSC (red) cardiomyocytes evoked by a voltage protocol of step to +20 mV for 150 ms and ramp of 120 ms back to the −40 mV holding potential.