Skip to main content
. 2012 Mar 1;8(3):e1002560. doi: 10.1371/journal.ppat.1002560

Figure 6. The impact of Notch signaling on Th1 differentiation is RBP-Jκ-independent.

Figure 6

(A) RBP-JκΔCD4Cre and RBP-Jκlox/lox mice were infected s.c. with 3×106 L. major and lesion size measured weekly. Group mean of lesion size ± SEM for n≥3 mice per group is shown. (B) Parasite load in footpad was analyzed by LDA 5 weeks post infection. Data represent mean parasite number ± SEM for n≥3 mice per group. (C, D) IFNγ (C), IL-4, IL-13 and IL-5 (D) levels were measured in supernatant of dLN cells isolated from L. major-infected mice 5 weeks post infection and restimulated for 72 h with or without UV-treated L. major. Group mean of cytokine secretion ± SEM is given (n≥3 mice per group). n.s. not significant. * p-value<0.05 versus control mice.