Figure 2.
Reduced rate of survival of neural progenitor cells in the dentate gyrus of Fmr1-KO mice. A. A dramatic reduction in the number of IdU+, surviving neural progenitor cells in the dentate gyrus of Fmr1-KO mice (*= p 0.0130, student’s t-test). B. A significant reduction in the number of surviving neuroblasts (IdU+Tuj1+) in the brains of Fmr1-KO mice (*= p 0.0077, student’s t-test). C. The number of surviving neuroblasts (IdU+Tuj1+) as a percentage of the number of surviving neural progenitor cells (IdU+) cells is unchanged in the dentate gyrus of Fmr1-KO compared to WT mice. D. IdU+ cells immunolabeled in brain sections of Fmr1-KO and WT mice. Lower panel: High power image of an IdU+Tuj1+ neuroblast in the dentate gyrus of WT mice. Scale bar= 50μ.