Table 4.
Results of the case-control association studies
| SNPs | Genotypea | P value | OR (95% CI)c | |||
|---|---|---|---|---|---|---|
| Control (n = 338) | Case (n = 389) | Genotype | Genotypeb | Allele | ||
| G1 | 133/156/49 | 169/171/49 | 0.548 | 0.192 | 0.270 | 0.886 (0.715–1.098) |
| G2 | 332/6/0 | 383/6/0 | 0.810 | 0.803 | 0.815 | 0.873 (0.280–2.720) |
| G3 | 264/68/6 | 318/59/12 | 0.117 | 0.607 | 0.508 | 0.896 (0.647–1.241) |
| G4 | 308/30/0 | 355/34/0 | 0.959 | 0.823 | 0.969 | 0.990 (0.599–1.636) |
| G5 | 242/91/5 | 301/83/5 | 0.218 | 0.145 | 0.104 | 0.778 (0.575–1.053) |
| G6 | 130/162/46 | 172/168/49 | 0.296 | 0.157 | 0.188 | 0.866 (0.699–1.073) |
| G7 | 317/21/0 | 370/19/0 | 0.445 | 0.566 | 0.451 | 0.786 (0.419–1.474) |
| G8 | 305/33/0 | 360/28/1 | 0.311 | 0.450 | 0.350 | 0.786 (0.474–1.304) |
| G9 | 322/16/0 | 364/24/0 | 0.382 | 0.303 | 0.389 | 1.324 (0.698–2.515) |
| G10 | 290/45/3 | 338/49/2 | 0.798 | 0.617 | 0.611 | 0.902 (0.605–1.344) |
| G11 | 338/0/0 | 384/2/0d | 0.184 | 0.999 | 0.184 | 1.003 (0.999–1.006) |
| G12 | 306/32/0 | 352/34/0d | 0.778 | 0.875 | 0.783 | 0.933 (0.569–1.529) |
| G13 | 226/103/9 | 277/103/6d | 0.294 | 0.127 | 0.135 | 0.809 (0.612–1.069) |
| G14 | 304/34/0 | 348/41/0 | 0.811 | 0.834 | 0.816 | 1.057 (0.663–1.686) |
| G15 | 307/31/0 | 351/38/0 | 0.765 | 0.760 | 0.770 | 1.075 (0.661–1.748) |
| G16 | 293/45/0 | 347/40/2 | 0.199 | 0.597 | 0.444 | 0.846 (0.551–1.299) |
OR odds ratio, CI confidence interval
aThe three values in the “genotype” column indicate the numbers of homozygotes (major allele)/heterozygotes/homozygotes (minor allele) in each SNP, respectively
bAfter adjusting for age and gender by logistic regression
cCalculated for the alleles
dGenotype data of three patients in G11, G12 and G13 were missing, respectively; no data were missing in the control group