Table 2.
Summary of genome wide association studies for the frequency of iNKT cells in the spleen.
| chromosome | position (Mb) | peak score | gene upstream | gene within | gene downstream |
|---|---|---|---|---|---|
| 4 | 143.03-143.09 | 5.22 | Pramef8 | Oog4 | Gm13043 |
| 5 | 82.90-82.93 | 5.10 | Lphn3 | NA | Mir1187 |
| 6 | 81.58-81.60 | 7.03 | Gm4408 | NA | Mir468 |
| 7 | 3.10-3.62 | 7.27 | NA |
AU018091, Mir290, Mir291a, Mir292, Mir291b, Mir293, Mir294, Mir295, Nlrp12, Myadm, Prkcc, Cacng7, Cacng8, Cacng6, Vstm1, Tarm1, Oscar, Ndufa2, Tfpt, Prpf31, Cnot3, Leng1 |
Tmc4 |
| 7 | 3.66-3.66 | 5.65 | Tsen34 | Rps9, Lilrb3 | Pira1 |
| 7 | 4.47-4.62 | 6.92 | Tnni1 | 6030429G01Rik, Syt5, Ptprh, Tmem86b, Ppp6r1, Hspbp1 |
Brsk1 |
| 7 | 4.69-4.84 | 7.58 | Tmem150b | Suv420h2, Cox6b2, Fam71e2, Il11, Tmem190, 2210411K11Rik, Rpl28, Ube2s, Shisa7, Isoc2b, Isoc2a |
Zfp628 |
| 7 | 13.58-13.87 | 7.41 | Zfp446 | Slc27a5, Zbtb45, Gm3901, Trim28, Chmp2a, Ube2m, Mzf1, Vmn1r85, Gm10301, Vmn1r87, Vmn1r88, Vmn1r89, 6330408A02Rik, Lig1 |
Pla2g4c |
| 7 | 14.00-14.02 | 5.95 | Gm10712 | Cabp5 | Bsph1 |
| 7 | 14.93-16.25 | 7.41 | Gm5585 | 2810007J24Rik, Vmn1r90, Gm4745, Gm9545, Obox2, Obox1, Obox3, Obox5 |
Obox5 |
| 7 | 16.48-16.49 | 6.26 | Crx | Crxos1 | Sepw1 |
| 7 | 20.65-21.97 | 7.70 | n-R5s152 | Vmn1r91, Gm16442, Vmn1r93, Vmn1r94, Gm17331, Gm4494, Gm6164, Gm4498, Gm5890, Gm4133, Gm4505, Gm5728, Vmn1r100, Vmn1r101, Gm10670, Vmn1r103, Vmn1r104, Gm5726, Gm4141, Vmn1r107, Gm4144, Gm5156, Vmn1r109, Vmn1r110, Vmn1r111, Gm10668, Vmn1r112, Vmn1r113, Vmn1r114, Vmn1r115, Vmn1r116, Vmn1r117, Vmn1r118, Vmn1r119, Gm4534, Vmn1r120, Vmn1r121, Vmn1r122, Vmn1r123 |
Vmn1r124 |
| 10 | 81.17-81.51 | 7.62 | Gm8117 | Gm8117, Gm3055, Gm8264, Gm4767, Gm8137, Zfp433, Zfp781, Gm8156, Gm8158, Gm8290, AL117821 |
Zfp873 |
| 12 | 98.42-98.45 | 7.29 | 1700019M22Rik | NA | Gm2417 |
| 12 | 99.76-99.79 | 5.09 | Gpr65 | Kcnk10 | Spata7 |
| 17 | 73.51-73.51 | 7.77 | Lbh | Lclat1 | Capn13 |
| 19 | 48.36-48.41 | 7.44 | Gm9494 | Sorcs3 | Gm4095 |
NA: not available. Chromosomal regions noted in bold and underlined contain a gene(s) commonly contributing to both thymic and splenic iNKT-cell levels.