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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Anesth Analg. 2011 Nov 3;115(2):305–308. doi: 10.1213/ANE.0b013e318239c6ca

Figure 4.

Figure 4

Inhibition of in vitro cortisol synthesis by methoxycarbonyl etomidate (MOC-etomidate) or its carboxylic acid metabolite (MOC-ECA). Cortisol concentrations were normalized to that measured in the absence of MOC-etomidate or MOC-ECA. Each data point is the mean normalized concentration obtained from 3 wells. The curves are fits of the MOC-etomidate and MOC-ECA concentration-response data to a Hill equation (slope = -1). The calculated IC50s were 0.10 ± 0.02 μM for MOC-etomidate and 30 ± 7 μM for MOC-ECA.