. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Anesth Analg. 2011 Nov 3;115(2):305–308. doi: 10.1213/ANE.0b013e318239c6ca

Table 1. Pharmacological activities of Etomidate, methoxycarbonyl (MOC)-etomidate, and MOC-ECA.

Assay	Etomidate	MOC-etomidate	MOC-ECA	MOC-etomidate/MOC-ECA
Loss of righting reflexes in tadpoles (EC₅₀)	2.3 ± 0.13 μM ^a	8 ± 2 μM^c	2,800 ± 640 μM	1/350
Direct activation of GABA_A receptors (EC₅₀)	_	10 ± 2.5 μM	3,500 ± 630 μM	1/350
Inhibition of in vitro cortisol synthesis (IC₅₀)	0.0013 ± 0.0002 μM ^b	0.10 ± 0.02 μM	30 ± 7 μM	1/300

From Husain et al.¹¹

From Cotten et al.⁸

From Cotten et al.¹