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. Author manuscript; available in PMC: 2013 Jan 19.
Published in final edited form as: Oncogene. 2011 Nov 21;31(29):3397–3408. doi: 10.1038/onc.2011.515

Figure 4. PAK1 kinase activity is required for anchorage-independent growth.

Figure 4

A. Anchorage-independent growth by HMLE expressing control vector, wild-type or kinase-dead PAK1 (PAK1K299R). Error bars = 1 SD. ** p-value <0.003 (compared to either vector or kinase-dead control). B. Expression level of PAK1 and its phosphorylation status at T423 and S144 in HMLE expressing vector control, PAK1 or PAK1K299R. C. Phosphorylation levels of three PAK1 substrates; RAF1S338, MEK1S298 and MerlinS518. Corresponding total protein levels are shown.