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. Author manuscript; available in PMC: 2013 Jan 19.
Published in final edited form as: Oncogene. 2011 Nov 21;31(29):3397–3408. doi: 10.1038/onc.2011.515

Figure 8. PAK1 simultaneously activates two distinct signaling pathways to promote transformation.

Figure 8

The model depicts PAK1 mechanism of action to activate the RAS-MAPK (Orange) pathway through direct activation of RAF1 and MEK1. The second arm (Purple) shows that PAK1 and Merlin are in an inhibitory loop, which can be pushed by PAK1 amplification and overexpression to inhibit Merlin that leads to MET signaling activation through GAB1.