Table 4.
Model of best fit in multiple linear regression analysis for mean daily phenprocoumon doses. Prior to analysis, square root transformation of daily phenprocoumon doses was performed. Dummy variables were created for VKORC1 genotypes with VKROC1 c.-1639GA as the reference group
| Genotype | R2 after entry, % | Adjusted R2 * after entry, % | Regression coefficient in final model | p value in final model |
|---|---|---|---|---|
| Intercept | 0.460 | |||
| VKORC1 c.-1639GG | 30.3 | 0.238 | <0.001 | |
| VKORC1 c.-1639AA | 39.3 | 37.6 | −0.271 | <0.001 |
| Height | 47.3 | 45.0 | 0.007 | 0.004 |
| Age | 51.4 | 48.6 | −0.004 | 0.018 |
Regression equation for estimating daily phenprocoumon dose: √daily phenprocoumon dose (mg) =0.460 + 0.238 (VKORC1 c.-1639GG) − 0.271 (VKORC1 c.-1639AA) + 0.007 (height) − 0.004 (age)