Table 5.
Model of best fit in multiple linear regression analysis for phenprocoumon plasma concentrations. Dummy variables were created for VKORC1 genotypes (VKROC1 c.-1639GA = reference group) and CYP2C9 (CYP2C9*1/*1 = reference group)
| Genotype | R2 after entry, % | Adjusted R2* after entry, % | Regression coefficient in final model | p value in final model |
|---|---|---|---|---|
| Intercept | 3.968 | |||
| VKORC1 c.-1639GG | 29.6 | 0.509 | 0.001 | |
| VKORC1 c.-1639AA | 40.0 | 38.3 | −0.690 | <0.001 |
| Age | 46.2 | 43.9 | −0.009 | 0.038 |
| CYP2C9*3 | 49.4 | 46.5 | 0.507 | 0.012 |
| CYP2C9*2 | 53.3 | 49.9 | 0.366 | 0.014 |
| √BMI | 56.6 | 52.8 | −0.321 | 0.026 |