Table 2.

List of up and down-regulated proteins detected in TLB extract.

No	Protein Name	Swiss-prot No	Score	MW	pI	Seq Cov	GRAVY	Function*
Up-regulated proteins
1	Calrecticulin	P27797	175	46890	4.3	18%	-1.104	Molecular calcium-binding chaperone
2	80 k protein H precursor	P14314	134	60245	4.34	17%	-0.910	Protein kinase C binding
3	Tropomyosin alpha-3 chain	P06753	55	32857	4.68	4%	-1.051	Regulates muscle contraction, stabilizes cytoskeleton actin filaments
4	Tropomyosin isoform	P09493	104	28519	4.89	14%	-1.044	Regulates muscle contraction, stabilizes cytoskeleton actin filaments
5	Protein disulfide isomerase (PDI)	P07237	45	57487	4.76	19%	-0.431	Catalyzes the formation, breakage and rearrangement of disulfide bonds
6	Heat shock protein 90 (HSP 90)	Q4R250	48	92572	4.77	10%	-0.719	Molecular chaperone that functions in the processing and transport of secreted proteins
7	Tubulin, beta polypeptide	Q91575	161	48142	4.7	15%	-0.355	Major constituent of microtubules
8	78 kDa glucose-regulated protein	P11021	505	72404	5.07	37%	-0.487	Anti-apoptosis, cellular response to glucose starvation
9	Heat shock protein 60 (HSP 60)	P10809	50	61348	5.7	17%	-0.076	Implicated in mitochondrial protein import and macromolecular assembly
10	Heat shock 70 kDa protein 8 isoform 1 (HSP 70)	P11142	220	71087	5.28	17%	-0.456	Molecular chaperone
11	Heat shock 70 kDa protein 1	Q5R7D3	257	69982	5.48	14%	-0.383	Stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol and within organelles
12	Protein disulfide isomerase A3 (PDI A3)	P30101	581	57167	5.98	21%	-0.506	Catalyzes the rearrangement of disulfide bonds in proteins
Down-regulated protein
13	Tubulin alpha-1 chain	Q6P9V9	235	50816	4.94	28%	-0.23	Major constituent of microtubules

*Functions were obtained from www.uniprot.org.