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. 2011 Dec 17;33(3):620–628. doi: 10.1093/carcin/bgr288

Fig. 2.

Fig. 2.

Effects of SFN on the activity of Nrf2 target proteins. (A–C) Enzyme activities were analyzed in lysates of the ileum and colon of WT (left parts) and GPx2-KO (right parts) mice adjusted to the indicated selenium status and treated with and without SFN for 4 weeks. (A) NQO1, (B) TrxR and (C) GST. All data represent mean ± SD of four animals measured in triplicate. Not to overload the figure, significance is only shown for the SFN effect. #P < 0.05, ##P < 0.01, ###P < 0.001 versus respective controls without SFN, analyzed with two-way analysis of variance with Bonferroni’s post tests. There were no significant differences between the genotypes. The higher basal activity of NQO1 in the SFN-untreated colon compared with ileum is significant in all selenium states (P < 0.01). The enhanced activity of TrxR with increasing selenium is significant by at least P < 0.05.