Table I.
Effects of GPx2, selenium and SFN on tumorigenesis in AOM/DSS-treated mice
| Diet | SFN (weeks) | GPx2+/+ |
GPx2−/− |
||
| Tumor incidence | Total tumor number* | Tumor incidence* | Total tumor number* | ||
| −Seo | 0 | 5/10 | 17 | 7/10 | 48 |
| 4 | 6/10 | 24 | 8/10 | 32 | |
| 3 | 5/10 | 30 | 9/10 | 58 | |
| +Seo | 0 | 4/10 | 13 | 4/10 | 28 |
| 4 | 4/10 | 31 | 5/10 | 37 | |
| 3 | 2/10 | 3a | 5/10 | 9a | |
| ++Seo | 0 | 5/10 | 9 | 7/10 | 19 |
| 4 | 7/10 | 12 | 5/10 | 27 | |
| 3 | 4/10 | 6 | 7/10 | 27a,b | |
Overall decrease of tumor numbers with increasing selenium supply and the presence of GPx2 was significant, o and *P < 0.05 (Fisher’s exact test) indicated at the left and lower edge. The effect of SFN in dependence of selenium, aP < 0.01 versus the respective selenium-poor group and bP < 0.01 versus the respective selenium-adequate group (Fisher’s exact test, pair-wise).