Table I.
Differentially expressed microRNAs between case and control groups
| Upregulated |
Downregulated |
||||||
| ID | Fold change | P value | FDR | ID | Fold change | P value | FDR |
| hsa-miR-216a | 3.58 | 1.77 × 10−25 | 1.78 × 10−23 | HS_228.1 | −3.66 | 1.38 × 10−30 | 2.70 × 10−28 |
| hsa-miR-588 | 3.14 | 6.28 × 10−25 | 4.09 × 10−23 | HS_108.1 | −3.27 | 2.64 × 10−17 | 5.17 × 10−16 |
| HS_33 | 2.99 | 4.76 × 10−32 | 1.40 × 10−29 | hsa-miR-92b | −2.46 | 1.88 × 10−35 | 1.10 × 10−32 |
| hsa-miR-521 | 2.81 | 3.88 × 10−17 | 7.12 × 10−16 | hsa-miR-374b | −2.35 | 1.84 × 10−21 | 7.22 × 10−20 |
| hsa-miR-675 | 2.62 | 2.22 × 10−25 | 1.87 × 10−23 | HS_31.1 | −2.27 | 4.95 × 10−11 | 3.02 × 10−10 |
| solexa-2683-338 | 2.57 | 1.56 × 10−24 | 9.14 × 10−23 | HS_257 | −2.11 | 4.29 × 10−15 | 5.24 × 10−14 |
| hsa-miR-1255b | 2.45 | 9.35 × 10−16 | 1.28 × 10−14 | hsa-miR-10b | −2.1 | 1.18 × 10−10 | 6.66 × 10−10 |
| HS_109 | 2.14 | 4.88 × 10−19 | 1.43 × 10−17 | hsa-miR-629* | −2.04 | 1.05 × 10−18 | 2.71 × 10−17 |
| hsa-miR-610 | 2.13 | 4.83 × 10−14 | 5.06 × 10−13 | hsa-miR-574-3p | −2.04 | 1.34 × 10−16 | 2.07 × 10−15 |
| HS_169 | 2.11 | 3.47 × 10−24 | 1.85 × 10−22 | hsa-let-7b* | −1.97 | 2.53 × 10−15 | 3.16 × 10−14 |
| solexa-15-44487 | 2.1 | 2.05 × 10−17 | 4.16 × 10−16 | hsa-miR-183 | −1.96 | 4.28 × 10−13 | 3.81 × 10−12 |
| hsa-miR-1225-3p | 2.06 | 8.59 × 10−14 | 8.41 × 10−13 | hsa-miR-182 | −1.91 | 4.50 × 10−11 | 2.78 × 10−10 |
| hsa-miR-140-5p | 2.04 | 4.58 × 10−06 | 1.30 × 10−05 | hsa-let-7e | −1.89 | 2.52 × 10−15 | 3.16 × 10−14 |
| hsa-miR-801:9.1 | 2.03 | 1.85 × 10−22 | 8.36 × 10−21 | hsa-miR-505* | −1.84 | 4.78 × 10−12 | 3.30 × 10−11 |
| hsa-miR-891a | 1.93 | 2.33 × 10−12 | 1.78 × 10−11 | hsa-miR-550 | −1.8 | 2.20 × 10−09 | 9.64 × 10−09 |
| solexa-8048-104 | 1.87 | 1.24 × 10−17 | 2.69 × 10−16 | hsa-miR-942 | −1.78 | 6.18 × 10−17 | 1.10 × 10−15 |
| hsa-miR-600 | 1.8 | 1.16 × 10−06 | 3.54 × 10−06 | HS_91.1 | −1.77 | 1.12 × 10−06 | 3.45 × 10−06 |
| HS_45.1 | 1.8 | 4.14 × 10−19 | 1.28 × 10−17 | hsa-miR-598 | −1.74 | 4.26 × 10−12 | 3.04 × 10−11 |
| hsa-miR-490-5p | 1.78 | 4.64 × 10−09 | 1.95 × 10−08 | hsa-miR-7-1* | −1.74 | 1.06 × 10−18 | 2.71 × 10−17 |
| solexa-603-1846 | 1.75 | 6.51 × 10−15 | 7.64 × 10−14 | hsa-miR-130b* | −1.73 | 1.98 × 10−18 | 4.85 × 10−17 |
| hsa-miR-20a* | 1.75 | 1.95 × 10−05 | 5.19 × 10−05 | hsa-miR-1301 | −1.73 | 1.93 × 10−12 | 1.49 × 10−11 |
| HS_260 | 1.74 | 6.04 × 10−27 | 8.86 × 10−25 | HS_10 | −1.72 | 3.44 × 10−10 | 1.77 × 10−09 |
| hsa-miR-330-5p | 1.74 | 3.96 × 10−10 | 1.99 × 10−09 | hsa-miR-193b* | −1.71 | 6.48 × 10−09 | 2.68 × 10−08 |
| hsa-miR-579 | 1.74 | 4.16 × 10−03 | 7.62 × 10−03 | hsa-miR-27a* | −1.71 | 5.76 × 10−08 | 2.10 × 10−07 |
| HS_128 | 1.72 | 2.77 × 10−14 | 3.01 × 10−13 | hsa-miR-29b-1* | −1.71 | 3.38 × 10−16 | 4.73 × 10−15 |
| hsa-miR-33a | 1.69 | 3.47 × 10−05 | 8.91 × 10−05 | hsa-miR-629 | −1.69 | 5.71 × 10−14 | 5.88 × 10−13 |
| hsa-miR-885-5p | 1.68 | 3.27 × 10−05 | 8.43 × 10−05 | hsa-miR-126* | −1.64 | 7.29 × 10−06 | 2.02 × 10−05 |
| hsa-miR-591 | 1.68 | 4.25 × 10−07 | 1.40 × 10−06 | hsa-miR-150 | −1.61 | 6.53 × 10−17 | 1.13 × 10−15 |
| HS_116 | 1.67 | 3.77 × 10−17 | 7.12 × 10−16 | hsa-miR-105* | −1.61 | 2.34 × 10−20 | 8.08 × 10−19 |
| hsa-miR-1268 | 1.67 | 2.99 × 10−09 | 1.27 × 10−08 | hsa-miR-30a* | −1.59 | 8.74 × 10−17 | 1.43 × 10−15 |
| HS_32 | 1.62 | 9.03 × 10−09 | 3.58 × 10−08 | hsa-miR-200c | −1.58 | 9.61 × 10−11 | 5.48 × 10−10 |
| hsa-miR-1322 | 1.62 | 1.74 × 10−09 | 7.84 × 10−09 | hsa-miR-628-3p | −1.57 | 3.60 × 10−11 | 2.25 × 10−10 |
| HS_175 | 1.61 | 6.48 × 10−18 | 1.52 × 10−16 | HS_67 | −1.57 | 1.94 × 10−13 | 1.84 × 10−12 |
| HS_112 | 1.59 | 6.53 × 10−07 | 2.10 × 10−06 | hsa-miR-200b | −1.55 | 1.98 × 10−13 | 1.85 × 10−12 |
| hsa-miR-335 | 1.58 | 1.80 × 10−14 | 1.99 × 10−13 | hsa-miR-342-5p | −1.55 | 2.60 × 10−08 | 9.78 × 10−08 |
| hsa-miR-612 | 1.58 | 2.24 × 10−08 | 8.49 × 10−08 | hsa-miR-1238 | −1.54 | 2.39 × 10−05 | 6.33 × 10−05 |
| hsa-miR-554 | 1.58 | 1.19 × 10−09 | 5.55 × 10−09 | hsa-miR-199a-3p, | −1.54 | 2.78 × 10−05 | 7.32 × 10−05 |
| hsa-miR-615-5p | 1.58 | 6.66 × 10−11 | 3.95 × 10−10 | hsa-miR-454* | −1.54 | 2.43 × 10−09 | 1.05 × 10−08 |
| HS_126 | 1.58 | 2.06 × 10−11 | 1.33 × 10−10 | hsa-miR-1287 | −1.52 | 2.70 × 10−11 | 1.71 × 10−10 |
| hsa-miR-1303 | 1.58 | 4.94 × 10−08 | 1.82 × 10−07 | hsa-miR-628-5p | −1.52 | 5.54 × 10−06 | 1.55 × 10−05 |
| hsa-miR-647 | 1.56 | 1.16 × 10−07 | 4.03 × 10−07 | hsa-miR-525-5p | −1.51 | 1.51 × 10−16 | 2.28 × 10−15 |
| solexa-9124-90 | 1.55 | 1.82 × 10−25 | 1.78 × 10−23 | ||||
| hsa-miR-21* | 1.54 | 2.07 × 10−04 | 4.79 × 10−04 | ||||
| hsa-miR-18b | 1.54 | 3.13 × 10−03 | 5.91 × 10−03 | ||||
| hsa-miR-326 | 1.54 | 9.12 × 10−07 | 2.86 × 10−06 | ||||
| HS_287 | 1.53 | 9.66 × 10−17 | 1.53 × 10−15 | ||||
| hsa-miR-296-5p | 1.53 | 1.88 × 10−06 | 5.56 × 10−06 | ||||
| hsa-miR-548g | 1.52 | 5.91 × 10−25 | 4.09 × 10−23 | ||||
| HS_282 | 1.52 | 6.95 × 10−17 | 1.17 × 10−15 | ||||
| hsa-miR-1281 | 1.52 | 7.22 × 10−11 | 4.21 × 10−10 | ||||
| hsa-miR-1226* | 1.52 | 9.54 × 10−10 | 4.52 × 10−09 | ||||
| hsa-miR-101 | 1.51 | 1.44 × 10−03 | 2.87 × 10−03 | ||||
| HS_147 | 1.51 | 5.25 × 10−15 | 6.29 × 10−14 | ||||
| hsa-miR-603 | 1.51 | 2.08 × 10−06 | 6.12 × 10−06 | ||||