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. 2009 Jun 5;9(6):4407–4445. doi: 10.3390/s90604407

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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 6. — SPR-based assays for pathogen detection. (A) Specific antibody is immobilised and is used to capture the pathogen leading to a signal. (B) Pathogen or pathogen-related antigen is captured. Specificity is conferred by the binding of a second antibody. (C) Specific antibody reacts with the pathogen or pathogen-related antigen. Non-bound (free) antibody is isolated and detected when bound to an immobilised antibody (normally an anti-species antibody) on the chip. In this case, the signal generated is inversely proportional to the pathogen concentration.