Table 1.
Effects of olmesartan on Oxidized low density lipoprotein (ox-LDL)-induced endothelial cell injuries in cultured endothelial cells.
| group | Cell vitality | LDH (U/L) | NO (μM) |
|---|---|---|---|
| Control | 100% | 40.2 ± 10.6 | 10.5 ± 0.9 |
| ox-LDL | 54.6% ± 9.2% * | 86.5 ± 20.4 * | 5.3 ± 1.2 * |
| ox-LDL+olmesartan | 78.1% ± 6.2% *# | 68.6 ± 13.7 *# | 7.4 ± 2.5 *# |
| olmesartan | 99.8% ± 1.2% # | 38.7 ± 10.2 # | 11.2 ± 1.8 # |
Cultured endothelial cells of neonatal rats were added by vehicle (Control), ox-LDL (200 μg/mL), olmesartan (10−5 M) or olmesartan plus ox-LDL for 24 h.
*
p < 0.05 vs. endothelial cells in Control;
#
p < 0.05 vs. endothelial cells treated with ox-LDL.
NO: nitrogen monoxide; LDH: Lactate Dehydrogenase; 1 Unit (U) is the amount of LDH that catalyzes the reaction of 1 μmol of substrate per minute, U/L, total LDH activity per 1 liter sample; μM, micro mole per liter.