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Changes of inhibitor-residue interaction energy caused by alanine scanning. Gray and red are used to represent the interactions of inhibitor with the residues of wild-type protein and mutated protein, respectively. (A) pDI6W-MDM2 complex; (B) WK23-MDM2 complex; (C) pDI6W-MDMX complex; and (D) WK23-MDMX complex.
