. 2012 Feb 17;13(2):2176–2195. doi: 10.3390/ijms13022176

Table 2.

Hydrogen bonds formed between the inhibitors and MDM2/MDMX.

Protein	Donor ^a	Acceptor	Distance(Å) ^b	Angle(°) ^b	Occupancy(%) ^c
MDM2	Trp23′-NE1-HE1	Leu54-O	2.92	146.79	97.20
	Phe19′-N-H	Gln72-OE1	3.01	151.71	71.34
	WK23-N8-H75	Leu54-O	2.90	154.12	98.95
MDMX	Trp23′-NE1-HE1	Met53-O	2.89	140.29	98.76
	Phe19′-N-H	Gln71-OE1	3.01	150.94	69.66
	WK23-N8-H103	Met53-O	2.92	153.75	99.29

The sign “′” represents the residue belonging to the peptide inhibitor pDI6W;

The hydrogen bonds are determined by the acceptor···donor atom distance of less than 3.5 Å and acceptor···H-donor angle of greater than 120°;

occupancy(%): to evaluate the stability and the strength of the hydrogen bond.