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Nr2e1frc/frc mice showed increased pain sensitivity. (a) The latency to lick paws as a sign of discomfort from heat is measured in the hot plate test. Nr2e1frc/frc mice took significantly less time to lick their paws compared to the Wt controls. * P < 0.05. (b) The tail flick test was also used to test pain sensitivity in these mice; however, there was no significant difference found between the two genotypes (P > 0.1).
