Table 1.

Therapeutic polyclonal and monoclonal antibodies against viruses.

Target	Name	Source	Major indication	Ref.
RSV	Respigam†	Human polyclonal immune globulin	Prophylactic treatment of RSV in infants	[82]
	Synagis†	Humanized monoclonal antibody	Prophylactic treatment of RSV in infants	[94]
Varicella Zoster virus (chicken pox)	VZIG† VariZIG†	Human polyclonal immune globulin	Prophylaxis against chickenpox	[83]
Vaccinia virus	VIG†	Human polyclonal immune globulin	Treatment of smallpox vaccine side effects	[84]
HBV	HepaGamB†	Human polyclonal immune globulin	Prevents HBV in patients receiving a liver transplant and in babies born to mothers infected with HBV	[85]
Rabies virus	HyperRab™ S/D† Imogam® Rabies-HT†	Human polyclonal immune globulin	Postexposure prevention of rabies	[86]
CMV	Cytogam†	Human polyclonal immune globulin	Prophylaxis of CMV disease associated with transplantations	[87]
HAV	GamaSTAN S/D†	Human polyclonal immune globulin	Postexposure prevention of hepatitis A	[88]
HCV	Civacir‡	Human polyclonal immune globulin	Prevent reinfection of HCV in HCV Ag-positive liver transplant patients	[101]
DENV	DENV1-E105‡ DENV1-E106‡	Mouse monoclonal antibodies	Therapeutic activity against DENV	[102,103]
Influenza A virus	TCN-032‡	Human monoclonal antibodies	Treatment of pandemic and severe seasonal influenza	[70,201]

^†Available commercially.

^‡Seeking commercial approval.

Ag: Antigen; DENV: Dengue virus; HAV: Hepatitis A virus; RSV: Respiratory syncytial virus.