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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: Future Oncol. 2012 Feb;8(2):145–150. doi: 10.2217/fon.11.147

Figure 2. 3-aminopyridine-2-carboxaldehyde thiosemicarbazone pharmacokinetics and methemoglobin pharmacodynamics.

Figure 2

Plasma concentration of 3-AP was determined in ten women with cervical cancer undergoing 3-AP radiochemotherapy. (A) Peak 3-AP concentration was observed at the end of a 2-h infusion. (B) Peak methemoglobin levels were detected 2 h after discontinuation of 3-AP infusion. (A & B) A vertical bar denotes the 4-h time point after the start of infusion.

3-AP: 3-aminopyridine-2-carboxaldehyde thiosemicarbazone; MetHgb: Methemoglobin.