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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Nat Neurosci. 2011 Oct 30;14(12):1607–1616. doi: 10.1038/nn.2959

Figure 3. Dynamic and stable 5-hmC DhMRs in cerebellum and hippocampus.

Figure 3

(a,e) P7 dynamic DhMRs, defined as DhMRs present at P7 relative to both 6 weeks and 1 year. Average normalized 5-hmC signals (reads per million divided by portion size) in ten equally sized DhMR portions upstream, in and downstream of DhMRs are plotted for each age. The total number of P7 cerebellum dynamic DhMRs (8,931) is indicated in the upper right-hand corner. Below is the identical analysis in hippocampus (404 total DhMRs). (b,f) 6 week dynamic DhMRs in cerebellum (1,206) and hippocampus (271) defined as DhMRs identified at 6 weeks relative to both P7 and 1 year. (c,g) Adult stable DhMRs in cerebellum (6,782) and hippocampus (90), defined as DhMRs identified at both 6 weeks and 1 year relative to P7. (d,h) 1 year–specific DhMRs in cerebellum (1,697) and hippocampus (107) defined as DhMRs identified at 1 year relative to both P7 and 6 weeks.