Table 3.
Change of risk factors of cardiovascular disease in the two study groups.
| Placebo | HPE | P value (Placebo versus HPE)‡ | |||||
|---|---|---|---|---|---|---|---|
| Baseline (n = 18) | End (n = 17) | Difference† | Baseline (n = 22) | End (N = 22) | Difference† | ||
| SBP (mmHg) | 132.1 ± 11.9a | 129.6 ± 15.1c | −0.8 ± 16.4c | 132.8 ± 11.24d | 135.5 ± 13.0b | 2.5 ± 11.3bd | 0.860 |
| DBP (mmHg) | 81.5 ± 6.1a | 85.0 ± 8.3c | 4.6 ± 10.5c | 83.9 ± 8.9 | 83.7 ± 9.0b | 0.5 ± 9.6b | 0.250 |
| FPG (mg/dL) | 101.8 ± 11.5 | 100.1 ± 9.7d | −1.9 ± 6.8d | 102.5 ± 13.32e | 97.0 ± 11.6f | −1.0 ± 9.3f | 0.842 |
| Insulin (μIU/mL) | 6.4 ± 3.7 | 5.0 ± 3.7 | −1.5 ± 3.8 | 7.9 ± 3.8d | 7.3 ± 5.0d | −1.2 ± 4.3 | 0.640 |
| HOMA-IR | 1.62 ± 1.02 | 1.13 ± 0.77 | −0.51 ± 0.93 | 1.95 ± 1.06d | 1.90 ± 1.42d | −0.05 ± 0.85d | 0.094 |
| QUICKI | 0.37 ± 0.04 | 0.40 ± 0.06 | 0.03 ± 0.04 | 0.35 ± 0.05 | 0.36 ± 0.05 | 0.01 ± 0.03 | 0.062 |
| Total cholesterol (mg/dL) | 186.0 ± 34.0 | 184.8 ± 35.0 | −2.1 ± 22.5 | 197.7 ± 36.9 | 195.4 ± 46.7 | −2.3 ± 25.0 | 0.843 |
| Triglyceride (mg/dL) | 149.9 ± 64.3 | 144.6 ± 47.8 | −8.4 ± 55.1 | 167.1 ± 83.3 | 143.3 ± 57.9d | −5.0 ± 61.2 | 0.966 |
| HDL cholesterol (mg/dL) | 51.8 ± 10.5 | 50.8 ± 5.9 | −0.8 ± 7.4 | 49.9 ± 9.0 | 50.2 ± 7.5 | 1.7 ± 7.1d | 0.480 |
| hs-CRP (mg/dL) | 0.12 ± 0.11d | 0.08 ± 0.05e | −0.36 ± 1.35e | 0.15 ± 0.15d | 0.17 ± 0.19d | 0.002 ± 0.105 g | 0.731 |
Mean ± SD, a1 data missing, b3 data missing, c5 data missing, d1 data exclusion d/t extreme value within group, e2 data exclusion d/t extreme values within group, f3 data exclusion d/t extreme values within group, g4 data exclusion d/t extreme values within group, †change from baseline (after-baseline), ‡P values are for the comparison between groups (change from baseline), HPE: human placental extract, SBP: systolic blood pressure, DBP: diastolic blood pressure, FPG: fasting plasma glucose, HOMA-IR: homeostasis model assessment of insulin resistance, QUICKI: the quantitative insulin sensitivity check index, HDL: high-density lipoprotein, and hs-CRP: high-sensitivity C reactive protein.