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. 2011 Dec 20;22(3):551–564. doi: 10.1038/cr.2011.205

Figure 3.

Figure 3

Activation of TRPV1 by dietary capsaicin up-regulates PGC-1α and improves mitochondrial function and muscle remodeling. (A-D) Protein expression of genes involved in fatty acid oxidation, glycolysis, fiber specification (A-C) and mitochondrial respiration (D) in skeletal muscles from WT and TRPV1−/− mice fed a regular diet (Con) or a capsaicin diet (Cap). (E) Mitochondrial mass in gastrocnemius muscle shown by transmission electron microscopy. (F) State 3 and state 4 respiration and respiratory control index (RCI) in mitochondria isolated from fresh quadriceps femoris muscles. (G) Percentage of type I fibers in gastrocnemius muscle shown by the metachromatic staining. Oxidative (Type I) fibers were stained dark blue. Data are means ± S.E.M. n = 3-8. *P < 0.05, **P < 0.01 vs WT.