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. 2011 Oct 25;22(3):528–538. doi: 10.1038/cr.2011.165

Figure 5.

Figure 5

Monoclonal antibodies against IL-17 ameliorated S-OIV H1N1-induced acute lung injury in mice. B6 mice were treated intravenously with 50 μg of isotype-control or anti-IL-17 antibodies per mouse 24 hours before infection and at 1 day and 3 DPI. (A) Mortality rates of BJ501-infected B6 mice (n = 10). (B) Changes in the body weights of B6 mice (n = 10). (C) Histological findings from lung tissues. Representative pathological images for the lungs at 5 DPI of mice infected with 105.5 TCID50 of BJ501 and intravenously treated with isotype-control or anti-IL-17 antibodies. The mean numbers of infiltrating cells per microscopic field ± SEM are shown (n = 100 fields analyzed for three mice per group). Magnification = 200×. (D) Wet-to-dry ratios of lungs at 5 DPI with BJ501 at 105.5 TCID50. The values are means ± SEM from six mice. *P < 0.05 and **P < 0.01. (E) Concentrations of specific inflammatory cytokines in the BALFs of BJ501-infected B6 mice at 24 hours post-infection were determined using a Bio-Plex Mouse Cytokine 23-Plex Array. *P < 0.05 and **P < 0.01.