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A cartoon depicting the heterogeneous nature of human hematopoietic stem/progenitor cell pool. Illustrated are three subsets (i.e., CD34+, CD90+, and CD49f+) of progenitors inside the Lin-CD38−CD45RA− population. Combined sorting of triple marker-positive (i.e., CD34+CD90+CD49f+; shaded) blood cells (in either bone marrow or cord blood) greatly enriches HSCs with long-term repopulating activity.
