TABLE 1.

Five recent notations supporting the importance for homicide as a means for β-cell destruction

1.	Tissue-specific cleavage appears critical to produce target autoantigenic peptides.
2.	Production of an antigenic peptide can occur directly in islet β-cells and not merely by antigen-presenting cells exposed to the target molecule.
3.	T-cells targeting multiple islet antigens are required to cause type 1 diabetes.
4.	Post-translational modification of peptide epitopes may be important to their antigenicity.
5.	Recognition of specific islet peptides appears to occur by conserved sequences of T-cell receptors.