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. 2011 Apr 23;60(5):1424–1434. doi: 10.2337/db10-1106

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 4. — Intraperitoneal and intracerebroventricular leptin are sufficient to alter body composition and serum insulin levels. Adipose tissue and gastrocnemius muscle weights in mice treated with intraperitoneal (A, C) or intracerebroventricular (B, D) leptin for 1 week are shown. GTTs (E, F) and serum insulin levels (G, H) before and 30 min after glucose injection are shown. Numbers of animals are indicated in each figure. For intraperitoneal leptin study, ^aP < 0.05 vs. wt RF; ^bP < 0.05 vs. ob/ob RF; ^cP < 0.05 vs. ob/ob CR. For intracerebroventricular leptin study, ^aP < 0.05 vs. wt CR intracerebroventricular saline; ^cP < 0.05 vs. ob/ob CR intracerebroventricular saline. icv, intracerebroventricular; L 1 wk, 1 week of leptin treatment; RF, random fed; wt, wild type.