TABLE 1.
Circulating lipid and hormone concentrations
| FFAs (mM) | Triglycerides (mg/dL) | Adiponectin (μg/mL) | Leptin (ng/mL) | |
|---|---|---|---|---|
| Pairfeeding studies | ||||
| Wt RF saline | 0.6 ± 0.1 (14) | 21.3 ± 3.0 (21) | 6.4 ± 1.0 (9) | 0.8 ± 0.2 (8) |
| Wt RF leptin | 0.6 ± 0.1c (11) | 15.9 ± 2.8b,c (21) | 6.4 ± 0.6c (10) | 1.2 ± 0.2 (6) |
| ob/ob RF saline | 0.9 ± 0.2a (11) | 30.8 ± 4.7 (11) | 8.7 ± 0.9 (11) | ND (6) |
| ob/ob RF leptin | 0.7 ± 0.1c (11) | 20.9 ± 2.2c (16) | 6.9 ± 0.8c (11) | 1.4 ± 0.3 (5) |
| ob/ob CR saline | 1.1 ± 0.2a (8) | 41.4 ± 5.3a (10) | 17.4 ± 1.3a,b (15) | ND (5) |
| db/db CR studies | ||||
| Wt RF | 0.7 ± 0.1 (8) | 21.3 ± 2.7 (13) | 5.6 ± 0.8 (6) | 0.8 ± 0.4 (7) |
| db/db RF | 1.5 ± 0.1a (4) | 42.6 ± 10.7a (7) | 8.9 ± 0.6 (7) | 63.8 ± 1.1a (4) |
| db/db CR | 1.4 ± 0.1a (6) | 34.6 ± 2. (11) | 14.6 ± 1.8a,b (10) | 17.6 ± 1.2a,b (4) |
Circulating concentrations of FFAs, triglycerides, adiponectin, and leptin were measured after 6 h of fasting (number of animals is indicated in parentheses).
aP < 0.05 vs. wt RF saline;
bP < 0.05 vs. ob/ob RF saline or db/db RF;
cP < 0.05 vs. ob/ob CR saline. ND, not detected; RF, random fed; wt, wild type.