FIG. 2.
PEDF alters whole-body fatty acid metabolism. A–C: Lean C57Bl/6 mice were injected with recombinant PEDF or sterile saline and placed in a metabolic monitoring station. Oxygen uptake (VO2; A) and total activity (B) were similar between groups. C: The respiratory exchange ratio (RER) was assessed during the light and dark cycles and was increased during the early phase of the light cycle in PEDF-treated mice (n = 6 mice per group). *P < 0.05 vs. vehicle at the corresponding time. D–F: VO2, activity, and the RER were assessed in ATGL−/− mice after recombinant PEDF or sterile saline administration (n = 4 per group). #P < 0.05, main effect for treatment. All data are presented as means ± SEM.