TABLE 1.

Phenotypic comparison of p110 control and knockout mice on normal chow

	p110-α+/+	p110-α−/−	p110-β+/+	p110-β−/−
Body weight (g)	22 ± 2	22 ± 1.6	22 ± 0.8	22 ± 1.3
%Body fat	18.3 ± 0.2	18.6 ± 0.5	17.2 ± 0.2	16.9 ± 0.2
Liver as % of body weight	4.00 ± 0.01	3.00 ± 0.02*	4.00 ± 0.02	4.00 ± 0.03
Liver triglyceride (mg/g)†	5.7 ± 0.9	4.1 ± 0.2*	5.1 ± 0.7	5.0 ± 0.2
Liver protein (mg/g)	346 ± 53	288 ± 20	326 ± 23	312 ± 52
Liver glycogen (mg/g)†	14.2 ± 0.3	5.8 ± 0.1*	13 ± 0.3	1.3 ± 0.3*
Blood chemistry†
ALT (units/L)	65 ± 19	44 ± 2	232 ± 21	156 ± 33
AST (units/L)	180 ± 44	215 ± 40	264 ± 67	271 ± 92
ALP (units/L)	85 ± 15	89 ± 10	85 ± 14	88 ± 2
Total bilirubin (mg/dL)	0.1 ± 0.02	0.3 ± 0.01	0.2 ± 0.01	0.2 ± 0.1
Cholesterol (mg/dL)	50 ± 9	39 ± 2	74 ± 10	64 ± 5
Triglyceride (mg/dL)	50 ± 4	41 ± 4	63 ± 12	59 ± 7
Albumin (g/dL)	2.3 ± 0.1	2.1 ± 0.2	2.7 ± 0.2	2.3 ± 0.3
Total protein (g/dL)	3.6 ± 0.3	3.3 ± 0.4	4.4 ± 0.4	3.9 ± 0.1
Glucose (mg/dL)	119 ± 2	118 ± 1	109 ± 4	150 ± 4*
Insulin (ng/mL)	1.96 ± 0.32	1.82 ± 0.21	0.75 ± 0.11	3.46 ± 0.53*

Data are means ± SE; N = 6 per group. ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase.

*P < 0.05.

†Animals were fasted for 6 h.