TABLE 2.
Blood chemistry comparison of p110 control and knockout mice on HFD
| p110-α+/+ | p110-α−/− | p110-β+/+ | p110-β−/− | |
|---|---|---|---|---|
| ALT (units/L) | 42 ± 5 | 39 ± 9 | 51 ± 16 | 48 ± 8 |
| AST (units/L) | 360 ± 58 | 245 ± 67* | 406 ± 131 | 366 ± 115 |
| ALP (units/L) | 62 ± 18 | 43 ± 8 | 86 ± 20 | 36 ± 5 |
| Total bilirubin (mg/dL) | 0.3 ± 0.15 | 0.2 ± 0.04 | 0.1 ± 0.04 | 0.1 ± 0.04 |
| Cholesterol (mg/dL) | 126 ± 19 | 83 ± 24 | 105 ± 14 | 134 ± 21 |
| Triglyceride (mg/dL) | 48 ± 11 | 41 ± 7 | 47 ± 16 | 46 ± 7 |
| Albumin (g/dL) | 2.3 ± 0.2 | 1.9 ± 0.2 | 2.6 ± 0.2 | 2.4 ± 0.2 |
| Total protein (g/dL) | 4.3 ± 0.3 | 3.3 ± 0.4 | 4.5 ± 0.4 | 4.3 ± 0.3 |
| Glucose (mg/dL) | 179 ± 31 | 208 ± 35 | 195 ± 14 | 186 ± 13 |
| Insulin (ng/mL) | 4.94 ± 0.92 | 5.42 ± 0.42 | 4.21 ± 2.50 | 5.46 ± 1.72 |
Data are means ± SE; N = 3 per group. ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase.
*P < 0.05. Animals were fasted for 6 h.