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. 2011 Apr 23;60(5):1512–1518. doi: 10.2337/db10-0956

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© 2011 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Regulation of CX3CL1 expression in human adipocytes by inflammation and PPAR-γ. Endotoxin (100 ng/mL) upregulated CX3CL1 relative mRNA expression (A) and secreted protein (B) in fully differentiated cultured human adipocytes. Similar upregulation was seen after stimulation with 10 ng/mL TNF-α and 5 ng/mL IFN-γ in CX3CL1 mRNA (C) and protein (D); the inflammatory stimulation was ablated completely by pretreatment of adipocytes with 10 μM PPAR-γ agonist GW347845 (representative experiment with n = 3 replicates). Values shown are means ± SD. *P < 0.01; **P < 0.01; ***P < 0.0001 compared with control levels.