TABLE 1.
Association of CX3CR1 polymorphisms rs3732378 and rs3732379 with metabolic traits in PennCAC
| CX3CR1 SNP | Alleles (minor allele) % | Waist β (P value) | HOMA-IR β (P value) | Leptin β (P value) | Adiponectin β (P value) | Met syn OR (P value) | T2D OR (P value) |
|---|---|---|---|---|---|---|---|
| — | n = 2073 | n = 1209 | n = 1336 | n = 1336 | n = 2077 | n = 2095 | |
| rs3732378 (T280M) | G/A (A) 0.18 | 0.50 (0.03) | 0.13 (0.003) | 0.08 (0.03) | −0.08 (0.02) | 1.20 (0.03) | 1.20 (0.05) |
| rs3732379 (V249I) | G/A (A) 0.29 | 0.38 (0.06) | 0.09 (0.02) | 0.05 (0.09) | −0.07 (0.03) | 1.13 (0.10) | 1.15 (0.08) |
Results are shown as β and P values for linear regression and odds ratios (ORs) and P values for logistic regression for minor allele as the risk allele using an additive model adjusted for age, sex, and smoking status. Waist, waist circumference; HOMA-IR, homeostasis model assessment of insulin resistance; Met syn, National Cholesterol Education Program–defined metabolic syndrome; T2D, type 2 diabetes.