FIG. 3.

Effect of C1-INH interventional treatment on diabetes-induced RVP. Diabetes was induced in rats by STZ injection. After confirmation of diabetes, rats were given 10-μL intravitreal injections of C1-INH (200 ng/eye) and BSS in the contralateral eye on days 2, 7, and 12. Retinal Evans blue-albumin permeation was measured on day 14 after diabetes onset. Diabetes treated with BSS increased RVP by 2.4-fold (**P < 0.001) compared with nondiabetic controls. Treatment of diabetes with C1-INH decreased RVP by 61% (τP = 0.003) compared with BSS-treated diabetes. Treatment of nondiabetic controls with C1-INH had no effect compared with nondiabetic BSS controls.