Table 4.
Measurement 1 vs. Measurement 2 in survivors and non-survivors a
| Hospital survivors (n = 71) |
Hospital non-survivors (n = 20) |
|||||
|---|---|---|---|---|---|---|
| Variable | Measurement 1 b | Measurement 2 c | p value | Measurement 1 b | Measurement 2 c | p value |
| Arginine | 48 (33 – 64) | 64 (50 – 89) | <0.001 | 49 (40.5 – 75.5) | 70 (61.5 – 78.5) | 0.008 |
| Ornithine | 28 (19 – 48) | 45 (30 – 61) | <0.001 | 39.5 (23 – 80) | 76.5 (55 – 92) d | 0.015 |
| Citrulline | 9 (7-13) | 14 (10-19) | <0.001 | 12 (4.5 – 18) | 18.5 (9.5 – 27.5) | 0.001 |
| ADMA | 461 (354 – 560) | 539 (433 – 681) | <0.001 | 596 (395 – 881.5) | 706.5 (577 – 842.5) e | 0.003 |
| SDMA | 735 (519 – 735) | 647 (457 – 1000) | 0.476 | 1125 (963.5 – 1555) | 1125 (925.5 – 2265) d | 0.093 |
| Arg/ DMA | 38 (26 – 52) | 52 (37 – 75) | <0.001 | 28 (21 – 38) | 32 (23 – 48) e | 0.179 |
| Arg/(Cit+Orn) | 1.12 (0.94 – 1.55) | 1.17 (0.85 – 1.47) | 0.125 | 0.95 (0.74 – 1.40) | 0.80 (0.58 – 1.13) e | 0.179 |
| Arg/ Orn | 1.61 (1.20 – 2.19) | 1.65 (1.11 – 1.96) | 0.062 | 1.31 (0.92 – 1.83) | 1.05 (0.74 – 1.51) e | 0.247 |
a
Values refer to median (interquartile range). Amino acid concentrations are micromolar, methylarginine concentrations are nanomolar, and methylarginine concentrations were converted to micromolar before calculation of the Arg/DMA ratio.
b
Samples for Measurement 1 were obtained 30 (20 – 39) hours after diagnosis
c
Samples for Measurement 2 were obtained 67 (48 – 72) hours after Measurement 1 and 90 (79 – 110) hours after diagnosis
d
p < 0.001 compared to corresponding Measurement 2 value in hospital survivors
e
p < 0.01 compared to corresponding Measurement 2 value in hospital survivors