. Author manuscript; available in PMC: 2012 Mar 2.

Published in final edited form as: Future Med Chem. 2011 May;3(7):821–833. doi: 10.4155/fmc.11.47

Table 3.

Cationic class PP2A activators.

Name (proposed mode of action)	Chemical structure	Biochemical assay				Cell-based assay
Name (proposed mode of action)	Chemical structure	Activity	Substrate	PP2A	Selectivities	Activity	Cell type
Memantine (I2)		0.1 μM reversed I2 inhibition	p-Tau (Ser199)	Brain holoenzyme	Not commented	Rescue at 10 μM	tau441-PC12 transfected with I2

C6-pyr-ceramide^† (direct, I2)		Rescue (0.25-1 μM; with I2)	Phosphorylated myelin basic protein	Heterotrimer	Inhibition of I2 is stereospecific for D-C6-erythro geometry	c-Myc dephosphorylation/degradation	A546 cells

^†

Also a member of sphingoids class.