Table 2.

Accuracy of clinical and pharmacogenetic algorithms in the retrospective validation cohort for days 6–11 of therapy.

Day of therapy	n*	Clinical R2†	Pharmacogenetic R2†	Clinical MAE‡	PGx MAE‡	p-value§
6	114	58.8%	70.6%	6.19	5.52	0.0408
7	142	60.4%	69.1%	5.18	5.00	0.1248
8	193	59.6%	67.9%	4.87	4.97	0.0264
9	106	65.3%	73.7%	5.12	4.23	0.0086
10	77	57.5%	59.0%	4.65	3.72	0.2263
11	27	84.4%	90.3%	5.46	4.46	0.2564

^*Note that individual participants may be included in more than one row (i.e. if they had more than one INR value), thus this column does not sum to the overall sample size;

^†R² is percent variation explained by the model;

^‡MAE is median absolute dosing error (mg/week);

^§Wilcoxon Signed Rank test for paired difference between PGx MAE and Clinical MAE.