Table 4.

Comparison of Adverse Events in P. aeruginosa Ulcers versus All Other Bacterial Ulcers

	P. aeruginosa (n = 110)*n (%)	All Other Bacteria (n = 384)*n (%)	Total n (%)	P†
Change in antibiotic/addition of other antibiotic	15 (14)	53 (14)	68 (14)	>0.99
Corneal perforation	2 (2)	13 (3)	15 (3)	0.54
Death	2 (2)	10 (3)	12 (2)	>0.99
IOP elevated >25 but ≤35 mm Hg with medications within 1 week of therapy‡	4 (4)	8 (2)	12 (2)	0.31
Increase in infiltrate size (>50%) and >1 mm in maximum diameter	1 (1)	12 (3)	13 (3)	0.32
No resolution of epithelial defect at 21 days or later	19 (17)	52 (14)	71 (14)	0.36
Progressive corneal thinning ≥50% of enrollment thickness	1 (1)	1 (0.3)	2 (0.4)	0.40
Recurrence of epithelial defect	1 (1)	7 (2)	8 (2)	0.69
Total subjects with any adverse events	27 (25)	76 (20)	103 (21)	0.29

^*Adverse events were recorded from enrollment until the 3-month follow-up. These values (n) reflect the number of cases at enrollment.

^†Fisher's exact test.

^‡IOP elevation >35 was considered a serious adverse event. There were no cases of IOP elevation >35 in SCUT.