Table 2.
General clinical presentations
| Sign/symptom | LD | PANDAS |
|---|---|---|
| Flu-like symptoms | +++a | +++ |
| Lethargy | +++ | ++ |
| Rash | ++ | NS |
| Sore throat | ++ | +++ |
| Other upper respiratory infection | ++ | ++ |
| Arthralgia | +++ | NS |
| Carditis | ++ | NS |
| Enuresis | NS | ++ |
| Headache | +++ | ++ |
| Neuropathies | +++ | +++ |
| Choreiform movements | NS | + |
| Neurological tics | + | +++ |
| Mood disturbances | +++ | + |
| Psychosis | + | + |
| Obsessions/compulsions | + | +++ |
| Hyperactivity | + | ++ |
| Problems concentrating | +++ | +++ |
| Separation anxiety | + | ++ |
| Handwriting changes | + | ++ |
| Decline in school performance | +++ | +++ |
| Suicidal ideations | + | NS |
| Homicidal ideations | NS | + |
Note:
a
Number of “+” symbols denotes relative reporting in referenced publications.
Abbreviations: LD, Lyme disease; NS, not significant; PANDAS, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.