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. Author manuscript; available in PMC: 2013 Jan 25.
Published in final edited form as: J Am Chem Soc. 2012 Jan 10;134(3):1673–1679. doi: 10.1021/ja2087147

Figure 1.

Figure 1

New 20-membered macrolactones 1315 and precursors A/B responsible for macrolactamization and macrolactonization, respectively (X; The nature of the leaving group at C-1 is unknown, so that X principally could be -OH, -SCoA or –SPKS, the latter two being the more likely cases).15