. Author manuscript; available in PMC: 2013 Jan 25.

Published in final edited form as: J Am Chem Soc. 2012 Jan 10;134(3):1673–1679. doi: 10.1021/ja2087147

Table 1.

Antiproliferative activity (IC₅₀ [ng/mL]), compared to geldanamycin 4, of new geldanamycin derivatives 8 – 12 against different cell lines: a permanent mouse line, four human cancer-derived lines, and a primary HUVEC (values shown are means of two parallel determinations).

	Cell line
	L-929 Mouse cell line	KB-3-1 Cervix carc.	PC-3 Prostate carc.	SK-OV-3 Ovarian carc.	A-431 Epidermoid carc.	HUVEC Primary cells
4	5.0	2.7	21	4.1	2.0	2.1
8	470	22	130	60	30	38
9	3200	210	600	380	270	210
10	>4000	640	2800	1900	1300	840
11	880	210	440	280	240	190
12	980	75	400	170	240	95